Disturbances of lipid metabolism in pancreatic disorders with special reference to serum lipoprotein lipase activity.

In order to clarify the mechanism of hyperlipemia during pancreatic disorders, investigations on changes of serum lipids, measurements of lipoprotein and number of chylomicra after oral administration of fat (safflower oil or olive oil) and studies on post-heparin lipoprotein lipase were done on patients with chronic pancreatitis and on dogs with experimental pancreatic disorders. The results obtained were as follows. ( 1) f3/a Lipoprotein indices and {3-lipoprotein levels were increased in pancreatitis. (2) There was an impaired removal of chylomicra from plasma in pancreatitis. (3) Post-heparin lipoprotein lipase activities in the dogs with pancrea tic disorders were significantly lower than those in the normal controls. ( 4) No inhibitor on lipoprotein lipase activity was detected in plasma in the dogs with pancreatitis. The possible relationships of these phenomena to the mechanism of lipid metabolism in pancreatic disorders have been discussed. It was concluded that the decreased delivery of the lipoprotein lipase into the circulation was one of the possible causes of hyperlipemia in pancr eatic disorders.